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Efficient Ball Mill Procedure In The ‘green’ Asymmetric Aldol Reaction

  • Direct Asymmetric Aldol Reaction Catalyzed By C2

    Direct Asymmetric Aldol Reaction Catalyzed By C2

    the tertiary amine-catalyzed direct asymmetric aldol reaction of 2-hydroxyacetophenones (2-hydroxy-1-arylethanones) with a variety of aliphatic aldehydes has been demonstrated. efficient ball

  • Efficient Ball Mill Procedure In The Green Asymmetric

    Efficient Ball Mill Procedure In The Green Asymmetric

    efficient ball mill procedure in the green asymmetric aldol reaction brnsted acids as additives for the direct asymmetric efficient ball-mill procedure in the 'green' asymmetric aldol reaction organocatalyzed by (s)-proline-containing dipeptides in the presence of water.

  • European Journal Of Organic Chemistry Earlyview

    European Journal Of Organic Chemistry Earlyview

      the reaction venues are different, but the synthetic targets are the same: single-layered long-range ordered 2d polymer molecules. this minireview collects and compares the first experiments helping to unravel the underlying mechanisms that afford these unique macromolecules by the controlled formation in the order of millions of covalent bonds per m 2 both in layered single crystals and on

  • Mechanochemistry Assisted Asymmetric Organocatalysis A

    Mechanochemistry Assisted Asymmetric Organocatalysis A

    among different organocatalysts used for asymmetric aldol reactions, proline and its derivatives emerged as powerful catalysts for the enamine activation of donor aldehyde or ketone. bolms group reported a solvent-free asymmetric organocatalytic aldol reaction under ball-milling conditions using l-proline (i) as catalyst (scheme 1) [2930].

  • Recent Approaches For Asymmetric Synthesis Of -Amino

    Recent Approaches For Asymmetric Synthesis Of -Amino

      motivated by the high efficiency of this approach to asymmetric synthesis of -amino--hydroxy acids, the aldol reaction of gly schiff base ni(ii) complex (r)-1 was applied for a rapid synthesis of the 18 f-labeled (t 1/2 110 min) analogue of l-threo-3,4-dihydroxyphenylserine, namely 6-l-threo-[18 f]fdops 126, which was demonstrated to be a

  • Clean And Efficient One-Pot Synthesis Of New 2-Oxo-2,3

    Clean And Efficient One-Pot Synthesis Of New 2-Oxo-2,3

      ball milling is a mechanical technique widely used for grinding solids with balls in a rotating vial to obtain fine particles [14]. ball milling has recently attracted increasing attention from organic chemists because of its simplicity, low cost, environmental friendliness, and capability to achieve high yields. various organic reactions

  • Solvent-Free Enantioselective Organocatalyzed Aldol Reactions

    Solvent-Free Enantioselective Organocatalyzed Aldol Reactions

    solvent media. the first solvent-free intermolecular aldol reaction involved the use of a ball mill [22]. this technique [23] is widely applied in grinding minerals and solids into fine particles and it was used in this transformation in order to enhance the efficient mixing of reagents and the catalyst. the best results

  • Top Files A Green Enantioselective Aldol Condensation

    Top Files A Green Enantioselective Aldol Condensation

    a popular reaction routinely discussed in introductory organic lectures and laboratories is the aldol condensation. two recent experiments outline aldol reactions from a green. a green enantioselective aldol condensation for the undergraduate organic laboratory bennett, george d. abstract. publication journal of chemical education.

  • Efficient Ball-Mill Procedure In The Green Asymmetric

    Efficient Ball-Mill Procedure In The Green Asymmetric

      the organocatalytic activity of (s)-proline-based dipeptides 1ac has been evaluated in the asymmetric aldol reaction between representative ketones with various aromatic aldehydes under solvent-free conditions in a ball mill.in particular, the methyl ester of (s)-proline-(s)-tryptophan, (s,s)-1c, proved to be an efficient organocatalyst, and the aldol reaction proceeded with good chemical

  • Bio-Renewable Enantioselective Aldol Reaction In Natural

    Bio-Renewable Enantioselective Aldol Reaction In Natural

    introduction organocatalyzed enantioselective reactions 1 have been proposed as ideal green processes, 2 as these procedures use only small organic molecules as catalysts in the absence of any type of metal. the epitome, among these processes, is the enantioselective cross-aldol reaction. 3 however, a close look at the reaction, as well as the synthetic protocols, forecasts some aspects that

  • Mechanochemistry Assisted Asymmetric

    Mechanochemistry Assisted Asymmetric

      aldol reaction. since the origin of organocatalysis, the asymmetric aldol reaction has been one of the most intensely studied reactions, providing an easy access to chiral -hydroxycarbonyl compounds, which are important building blocks for various bioactive molecules .among different organocatalysts used for asymmetric aldol reactions, proline and its derivatives emerged as

  • (Pdf) Solvent-Free Asymmetric Aldol Reaction

    (Pdf) Solvent-Free Asymmetric Aldol Reaction

    the anti-aldol adduct was obtained in high yield and with ball-milling (hsbm) is a sustainable mechanochemical technique, good diastereo- and enantioselectivity (up to 69:31 dr, up to 88 which is being increasingly used in synthetic organic chemistry to ee).7 recently, as part of our continuing interest in synthetic ap- promote several

  • Highly Efficient Small Organic Molecules For

    Highly Efficient Small Organic Molecules For

      efficient ball-mill procedure in the green asymmetric aldol reaction organocatalyzed by (s)-proline-containing dipeptides in the presence of water. tetrahedron 2011, 67 (36) , 6953-6959. doi: 10.1016/j.tet.2011.06.042.

  • Rua A Highly Efficient Solvent-Free Asymmetric Direct

    Rua A Highly Efficient Solvent-Free Asymmetric Direct

    a highly efficient solvent-free asymmetric direct aldol reaction organocatalyzed by recoverable (s)-binam-l-prolinamides. and ball mill technique. these procedures allow one to reduce not only the amount of required ketone to 2 equiv but also the reaction time to give the aldol products with regio-, diastereo-, and enantioselectivities

  • Cheminform Abstract Efficient Ball-Mill Procedure In The

    Cheminform Abstract Efficient Ball-Mill Procedure In The

    cheminform abstract: efficient ball-mill procedure in the green asymmetric aldol reaction organocatalyzed by (s)-proline-containing dipeptides in the presence of water. september 2011

  • Aqueous Formic Acid An Efficient, Inexpensive And

    Aqueous Formic Acid An Efficient, Inexpensive And

      in this article, we present a convenient and green method for synthesis of -amino carbonyl compounds through ball-milling technique by using aqueous formic acid, which is an inexpensive and highly efficient catalyst. this multi-component reaction was done at room temperature with high anti-selectivity and easy workup. the use of solvent-free ball-milling technique helped to

  • Ball Milling Towards Green Synthesis Applications

    Ball Milling Towards Green Synthesis Applications

    chapter 5, cross dehydrogenative coupling reactions by ball milling by jingbo yu, zhijiang jiang and weike su (zhejiang university of technology, china) confirms how ball milling can promote cross dehydrogenative coupling (cdc) and asymmetric cdc reactions. this method efficiently provides cc bonds directly from ch bonds.

  • Mechanochemistry Assisted Asymmetric Organocatalysis A

    Mechanochemistry Assisted Asymmetric Organocatalysis A

    beilstein j. org. chem. 2012, 8, 21322141. 2135 scheme 4: asymmetric aldol reaction assisted by ball-milling catalysed by dipeptides (a) with iii and (b) with iv. the methyl ester of (s)-proline-(s)-tryptophan (iv) was shownto be an efficient organocatalyst for asymmetric aldol reactions of ketones with aromatic aldehydes in the presence of water by

  • Mechanochemistry As An Emerging Tool For Molecular

    Mechanochemistry As An Emerging Tool For Molecular

      pioneering investigations of mechanochemical (s)-proline-catalyzed asymmetric aldol reactions were carried out by bolm and co-workers, affording anti-aldol products in high yield and with up to 99 ee . 56 when comparing the reaction of 4-nitrobenzaldehyde 21 with tetrahydrothiopyran-4-one 22 to analogous solution reactions, a higher yield was

  • Starting A Cement Grinding Mill Factory

    Starting A Cement Grinding Mill Factory

    efficient ball mill procedure in the green asymmetric aldol reaction china cement mill factory best price cement mill made its characteristics are high grinding efficiency and low power consumption.the cement mill with high fineness and high yield mainly adopts the advanced internal powder selecting special silo separation device and the

  • Mechanochemical Synthesis Of Small Organic Molecules

    Mechanochemical Synthesis Of Small Organic Molecules

      aldol reaction. in 2000, raston and scott first reported the aldol condensation reaction using veratraldehyde, 4-phenylcyclohexanone and 1-indanone in the presence of naoh in a vibrating ball mill and the products were obtained in the yield up to 98 within 10 min .

  • Cmc Catalyzed Multicomponent Mannich Reaction For

    Cmc Catalyzed Multicomponent Mannich Reaction For

    reactions were performed by using a ball mill mm-400 from retsch company equipped with stainless steel grinding jars (10 ml). two stainless steel balls with 7 mm diameter were used, and the milling frequency was set at ca. 28 hz. 2.2. general procedure for synthesis of 2-hydroxy-1,4-naphtoquinones 4

  • Full Procedure Of Cement Formation

    Full Procedure Of Cement Formation

    september 1, 2003 concrete manual 5-694.500 cement is furnished, assure the full content of each sack is placed in the mixer. 6. the use of dirty or contaminated aggregates results in a lower bond strength between the cement paste and the aggregates, thus producing a poorer quality cement paste, thereby reducing concrete strength.

  • A Highly Efficient Solvent-Free Asymmetric Direct Aldol

    A Highly Efficient Solvent-Free Asymmetric Direct Aldol

      recoverable (sa)-binam-l-prolinamide in combination with benzoic acid is used as catalysts in the direct aldol reaction between cycloalkyl, alkyl, and -functionalized ketones and aldehydes under solvent-free reaction conditions. three different methods are assayed: simple conventional magnetic stirring, magnetic stirring after previous dissolution in thf and evaporation,

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